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GW 4869 dihydrocloride

Catalog#: 2417-1
Size: 1 mg
Price: 1125 (RMB)

Product Name: GW 4869 dihydrocloride Alternate Name/Synonyms: 3,​3’-​(1,​4-​phenylene)bis[N-​[4-​(4,​5-​dihydro-​1H-​imidazol-​2-​yl)phenyl]-​2-​propenamide, dihydrochloride; GW69A; GW554869A Description: GW 4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC₅₀ = 1 μM), but does not affect acid sphingomyelinase activity. It inhibits TNF-α-mediated sphingomyelin hydrolysis (100% inhibition at 20 μM) and TNF-α-induced cell death in MCF7 cells without interfering with activation of NF-κB or glutathione depletion in response to TNF. Peptide Sequence: N/A Appearance: Pale yellow solid Formulation: N/A CAS Number: 6823-69-4 Molecular Formula: C30H20N6O2 . 2HCl [xH2O] Molecular Weight: 577.5 Purity: ≥90% Solubility:DMSO (~0.2 mg/ml) Storage Temp.: -20 ̊C Shipping Conditions: gel pack Handling: Protect from air and moisture SMILES: C1CN=C(N1)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(C=C3)C=CC(=O)NC4=CC=C(C=C4)C5= InChi: InChI=1S/C30H28N6O2.2ClH/c37-27(35-25-11-7-23(8-12-25)29-31-17-18-32-29)15-5-21-1-2-22(4-3-21)6-16-28(38)36-26-13-9-24(10-14-26)30-33-19-20-34-30;;/h1-16H,17-20H2,(H,31,32)(H,33,34)(H,35,37)(H,36,38);2*1H/b15-5+,16-6+;; InChi Key: NSFKAZDTKIKLKT-CLEIDKRQSA-N PubChem CID: 16078967 MDL Number: N/A USAGE: For Research Use Only! Not For Use in Humans.
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