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Phlorizin

Catalog#: 2416-500
Size: 500 mg
Price: 2925 (RMB)
 


Product Name: Phlorizin

Alternate Name/Synonyms: 1-​[2-​(β-​D-​glucopyranosyloxy)-​4,​6-​dihydroxyphenyl]-​3-​(4-​hydroxyphenyl)-​1-​propanone; NSC 2833; Florizidin

Description: Phlorizin is a competitive inhibitor of SGLT1 (sodium glucose co-transporter 1) and SGLT2 (sodium glucose co-transporter 2); this reduces renal glucose transport, lowering the amount of glucose in the blood. It competitively inhibits the initial rate of α-methyl-D-glucopyranoside (α-MDG) uptake in human COS-1 cells expressing hSGLT1 and hSGLT2 with IC₅₀ values of 400 and 65 nM, respectively. In HEK293T cells expressing human SGLT1 and SGLT2, phlorizin exhibits Ki values of 140 and 11 nM, respectively, at 37°C.

Peptide Sequence: N/A

Appearance: White to yellow solid

Formulation: N/A

CAS Number: 60-81-1

Molecular Formula: C21H24O10

Molecular Weight: 436.41

Purity: ≥98%

Solubility:DMSO (~30 mg/ml) or EtOH (~ 5 mg/ml)

Storage Temp.: -20 ̊C

Shipping Conditions: gel pack

Handling: Protect from light and air

SMILES: C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2OC3C(C(C(C(O3)CO)O)O)O)O)O)O

InChi: InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1

InChi Key: IOUVKUPGCMBWBT-QNDFHXLGSA-N

PubChem CID: 6072

MDL Number: MFCD00149438

USAGE: For Research Use Only! Not For Use in Humans.

 
 
 
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