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GW-5074

Catalog#: 2412-25
Size: 5 mg
Price: 6825 (RMB)
 


Product Name: GW-5074

Alternate Name/Synonyms: 3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydroindol-2-one

Description: Cell-permeable. A potent inhibitor of cRAF1 kinase (IC₅₀ = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective effects in vivo via a mechanism that is independent of MEK, ERK, and Akt signaling.

Peptide Sequence: N/A

Appearance: Dark orange solid

Formulation: N/A

CAS Number: 220904-83-6

Molecular Formula: C15H8Br2INO2

Molecular Weight: 520.95

Purity: ≥98% by TLC

Solubility:DMSO (~50 mg/ml)

Storage Temp.: -20 ̊C

Shipping Conditions: gel pack

Handling: Protect from light and air

SMILES: C1=CC2=C(C=C1I)C(=CC3=CC(=C(C(=C3)Br)O)Br)C(=O)N2

InChi: InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-

InChi Key: LMXYVLFTZRPNRV-KMKOMSMNSA-N

PubChem CID: 5924208

MDL Number: MFCD03453076

USAGE: For Research Use Only! Not For Use in Humans.

 
 
 
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