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HPI-1

Catalog#: 2410-25
Size: 5 mg
Price: 6825 (RMB)
 


Product Name: HPI-1

Alternate Name/Synonyms: 2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate

Description: HPI-1 is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. Inhibits both endogenous and exogenous Gli1/Gli2 activity. IC₅₀’s range from 0.2 to 6 µM for various cell-based assays.

Peptide Sequence: N/A

Appearance: Yellow solid

Formulation: N/A

CAS Number: 599150-20-6

Molecular Formula: C27H29NO6 . XH2O

Molecular Weight: 463.52

Purity: ≥98% by TLC

Solubility:DMSO (~25 mg/ml) or EtOH (~25 mg/ml)

Storage Temp.: -20 ̊C

Shipping Conditions: gel pack

Handling: Protect from light and air

SMILES: CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC.O

InChi: InChI=1S/C27H29NO6.H2O/c1-16-24(27(31)34-12-11-32-2)25(17-7-6-8-19(29)13-17)26-21(28-16)14-18(15-22(26)30)20-9-4-5-10-23(20)33-3;/h4-10,13,18,25,28-29H,11-12,14-15H2,1-3H3;1H2

InChi Key: BOASXIAGFOONSK-UHFFFAOYSA-N

PubChem CID: 71311904

MDL Number: MFCD17215941

USAGE: For Research Use Only! Not For Use in Humans.

 
 
 
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