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(-)-Blebbistatin

Catalog#: 2406-1
Size: 1 mg
Price: 1125 (RMB)
 


Product Name: (-)-Blebbistatin

Alternate Name/Synonyms: 1,​2,​3,​3a-​tetrahydro-​3aS-​hydroxy-​6-​methyl-​1-​phenyl-​4H-​Pyrrolo[2,​3-​b]quinolin-​4-​one; (S)-Blebbistatin

Description: Cell-permeable. The active enantiomer of (±)-Blebbistatin (Cat. No. 2405). A selective inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀ = 0.5-5.0 μM), while weakly inhibiting smooth muscle myosin (IC₅₀ = 80 μM). Through these effects, (-)-blebbistatin reversibly blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells.

Peptide Sequence: N/A

Appearance: Yellow solid

Formulation: N/A

CAS Number: 856925-71-8

Molecular Formula: C18H16N2O2

Molecular Weight: 292.34

Purity: ≥98% by HPLC

Solubility:DMSO (~25 mg/ml)

Storage Temp.: -20 ̊C

Shipping Conditions: gel pack

Handling: Protect from light and air

SMILES: CC1=CC2=C(C=C1)N=C3C(C2=O)(CCN3C4=CC=CC=C4)O

InChi: InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1

InChi Key: LZAXPYOBKSJSEX-GOSISDBHSA-N

PubChem CID: 5287792

MDL Number: MFCD08460907

USAGE: For Research Use Only! Not For Use in Humans.

 
 
 
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