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Procathepsin K, rat recombinant

Catalog#: 1029-50
Size: 50 μg
Price: 13425 (RMB)
 


Product Name: Procathepsin K, rat recombinant

Alternate Name/Synonyms: CTSK, CTSO, CTSO3

Gene Symbol: CATK

Accession #: P00786

Gene ID: 25425

Source: E. coli.

Appearance: Liquid

Physical Form Description: 1 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0).

Molecular Weight: 35.4 kDa

Purity by SDS-PAGE: ≥95%

Purity by HPLC: N/A

Endotoxin Level: N/A

Biological Activity: The specific activity is >400 mU/mg (1U = 1 µmole/min/mg) as measured by Cathepsin K Activity Assay Kit (Catalog # K141-100)

Reconstitution Instructions: N/A

Storage Temp.: -80°C

Shipping: Dry ice

Background Information: Cathepsin K, a member of the papain cysteine proteinase family, is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is produced as an inactive proenzyme (35.4 kDa) that is converted to its mature active form (23.5 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.

Amino Acid Sequence: N/A

Handling: Centrifuge the vial prior to opening

USAGE: For Research Use Only! Not For Use in Humans.

 
 
 
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