TM C-reactive/CRP, human recombinant>
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Human CellExpTM C-reactive/CRP, human recombinant

Catalog#: 7242-100
Size: 100 μg
Price: 1875 (RMB)
 


Product Name: Human CellExp™ C-reactive/CRP, human recombinant

Alternate Name/Synonyms: CRP, PTX1, C-reactive protein

Gene Symbol: CRP

Accession #: P02741

Gene ID: 1401

Source: HEK 293 cells

Appearance: Lyophilized powder

Physical Form Description: Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Molecular Weight: This is a 206 amino acids protein with polyhistidine tag at C-terminus, and has a calculated MW of 24 kDa. The predicted N-terminal is Phe17. DTT-reduced protein migrates as 26 kDa protein.

Purity by SDS-PAGE: ≥95%

Purity by HPLC: N/A

Endotoxin Level: < 0.1 ng/μg of protein (<1EU/μg).

Biological Activity: N/A

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Storage Temp.: -20°C

Shipping: Gel pack

Background Information: C-reactive protein (CRP) is a member of the pentraxin family of proteins that are characterized by a cyclic pentameric structure. Human CRP gene encodes a 224 amino acids precursor. The mature human CRP protein has 206 amino acids that are noncovalently linked to form the pentameter. Human CRP shares 71% and 64% amino acid sequence homology with mouse and rat respectively. CRP, synthesized by hepatocytes, is a major acute phase serum protein in human. IL6, IL1 and glucocorticoids are the major inducer of the CRP gene. The physiological role of CRP is to bind to phosphocholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system. CRP binds to phosphocholine on microbes and damaged cells and enhances phagocytosis by macrophages. Thus, CRP participates in the clearance of necrotic and apoptotic cells. CRP rises up to 50,000-fold in acute inflammation, such as infection. It rises above normal limits within 6 hours, and peaks at 48 hours. Its half-life is constant, and therefore its level is mainly determined by the rate of production. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases.

Amino Acid Sequence: N/A

Handling: Centrifuge the vial prior to opening

USAGE: For Research Use Only! Not For Use in Humans.

 
 
 
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