TM Olfactomedin, human recombinant>
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Human CellExpTM Olfactomedin, human recombinant

Catalog#: 7225-10
Size: 10 μg
Price: 2925 (RMB)

Product Name: Human CellExp™ Olfactomedin, human recombinant

Alternate Name/Synonyms: OLFM4, GC1, GW112, Olfactomedin-4, KIAA4294, OLM4, OlfD, UNQ362, hGC-1, hOLfD

Gene Symbol: OLFML1

Accession #: Q6UWY5

Gene ID: 283298

Source: HEK 293 cells

Appearance: Lyophilized powder

Physical Form Description: Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Molecular Weight: This protein is fused with 6 × His tag at the N-terminus, has a calculated MW of 56 kDa. The predicted N-terminus is Asp 21. DTT-reduced protein migrates as 65-70 kDa due to glycosylation.

Purity by SDS-PAGE: ≥95%

Purity by HPLC: N/A

Endotoxin Level: < 0.1 ng/μg of protein (<1EU/μg).

Biological Activity: N/A

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Storage Temp.: -20°C

Shipping: Gel pack

Background Information: Olfactomedin-4 (OLM-4) also known as OLFM4, antiapoptotic protein GW112, G-CSF-stimulated clone 1 protein (hGC-1), hOLfD, is a secreted protein which contains one olfactomedin-like domain. OLFM4 is expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues. OLFM4 may promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. OLFM4 may play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. The human OLFM4 is also thought to be a useful marker for early myeloid development.

Amino Acid Sequence: N/A

Handling: Centrifuge the vial prior to opening

USAGE: For Research Use Only! Not For Use in Humans.

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