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EDEM2 Antibody

Catalog#: 6633-100
Size: 100 μg
Price: 4125 (RMB)

Product Name: EDEM2 Antibody

Antibody Target: EDEM2

Alternative Name: ER degradation-enhancing alpha-mannosidase-like protein 2

Host: Rabbit

Antibody Type: Polyclonal

Isotype: Rabbit IgG

Immunogen: Synthetic peptide C-terminal

Accession#: Q9BV94

Gene ID: 55741

Appearance: Colorless liquid

Concentration: 0.5 mg/ml

Formulation: 100 µg (0.5 mg/ml) polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Purification: Affinity purified antibody

Species Reactivity: Human, mouse, rat

Application: Western blot

Positive Control: Western Blot: Rat kidney lysate

Application & Usage: Western blot: 1:200

Storage Temp.: -20 °C

Shipping: gel pack

Background Descriptions: Proteins expressed in the endoplasmic reticulum (ER) are tightly regulated by a variety of quality control mechanisms. Terminally misfolded proteins in the ER are retrotranslocated to the cytoplasm and degraded by proteasomes through a mechanism known as ER-associated degradation (ERAD). EDEM2 (ER degradation-enhancing alpha-mannosidase-like 2) is a 578 amino acid secreted protein that, in conjunction with other EDEM proteins (namely EDEM and EDEM3), is involved in the ERAD pathway of protein degradation. EDEM2, a member of the glycosyl hydrolase 47 family, contains a mannosidase homology domain, an N-terminal cleavable signal sequence and a C-terminal extension that is required for both ER retention and the proper function of EDEM2. Human EDEM2 shares 93% sequence identity with its mouse homolog, suggesting a conserved role between species. Two isoforms of EDEM2 exist due to alternative splicing events.

Handling: The antibody solution should be gently mixed before use

USAGE: For Research Use Only! Not For Use in Humans.

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